Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia
Universal BE-CAR7 T cells induced leukemic remission in patients with relapsed or refractory T-cell ALL, thus allowing successful allogeneic hematopoietic stem-cell transplantation in most of the patients. (Funded by the Medical Research Council and others; ISRCTN Registry number, ISRCTN15323014.).
Authors
- Batoul Ahmed
- Jan Chu (ORCID: https://orcid.org/0000-0002-5786-2109)
- Rebecca Thomas
- Christos Georgiadis (ORCID: https://orcid.org/0000-0003-0031-8396)
- Roland Preece
- Waseem Qasim (ORCID: https://orcid.org/0000-0001-8353-4494)
- Avijeet Kumar Mishra (ORCID: https://orcid.org/0000-0003-3745-835X)
- Deborah Yallop
- Stuart Adams (ORCID: https://orcid.org/0000-0002-2650-2848)
- David O’Connor (ORCID: https://orcid.org/0000-0003-3542-5976)
- Prudence Hardefeldt
- Annie Etuk (ORCID: https://orcid.org/0000-0001-6626-8761)
- Kimberly Gilmour (ORCID: https://orcid.org/0000-0003-0285-3958)
- Robert Chiesa (ORCID: https://orcid.org/0000-0001-9323-0259)
- Hani Rashed
- Jemma Selvage
Institutions
- Great Ormond Street Hospital (GB)
- King's College Hospital NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1056/nejmoa2505478
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14