Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool

All three activation techniques performed similarly, based on the NIST/NIJ DIT results. However, IS-CID produced significantly less fragmentation than CID or AIF, indicating that AIF is a suitable screening technique for this instrumental setup. The NIST/NIJ DIT can also be utilized for ESI-CID spectra, although slightly fewer nitazene analogs were correctly identified with ESI-CID than with DART-CID.

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Publication Details

Journal
Rapid Communications in Mass Spectrometry
Published
2025-12-08
DOI
https://doi.org/10.1002/rcm.70004
Primary Topic
Chemical Reactions and Mechanisms
Type
article
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article

Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool

Alleigh N. Couch, J. Tyler Davidson, Emma K. Hardwick
Rapid Communications in Mass Spectrometry
Chemical Reactions and Mechanisms
article

Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool

Alleigh N. Couch, J. Tyler Davidson, Emma K. Hardwick
article en

Abstract

All three activation techniques performed similarly, based on the NIST/NIJ DIT results. However, IS-CID produced significantly less fragmentation than CID or AIF, indicating that AIF is a suitable screening technique for this instrumental setup. The NIST/NIJ DIT can also be utilized for ESI-CID spectra, although slightly fewer nitazene analogs were correctly identified with ESI-CID than with DART-CID.

Rapid Communications in Mass SpectrometryVol. 40(5)
Sam Houston State University (US)
Openalex Percentile: Top 65%
Chemical Reactions and Mechanisms
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