Personalized Fluid Management in Patients With Sepsis and Acute Kidney Injury: A Causal Machine Learning Approach
Causal-ML framework outperformed random forest model in identifying patients with AKI and sepsis who benefit from restrictive fluid therapy. This provides a data-driven approach for personalized fluid management and merits prospective evaluation in clinical trials.
Authors
- Hernando Gómez (ORCID: https://orcid.org/0000-0001-5605-3513)
- Khaled Shawwa (ORCID: https://orcid.org/0000-0001-8849-5244)
- Kullaya Takkavatakarn (ORCID: https://orcid.org/0000-0002-6236-8893)
- Michael Sterling
- Patricia Kovatch (ORCID: https://orcid.org/0000-0001-8368-1742)
- Ashwin Sawant (ORCID: https://orcid.org/0000-0003-1525-8541)
- John A. Kellum (ORCID: https://orcid.org/0000-0003-1995-2653)
- Zainab Al-Taie (ORCID: https://orcid.org/0000-0003-2624-2035)
- Won-Suk Oh (ORCID: https://orcid.org/0000-0003-0874-5026)
- Girish N. Nadkarni (ORCID: https://orcid.org/0000-0001-6319-4314)
- Pranai Tandon (ORCID: https://orcid.org/0000-0001-5101-7310)
- Hannah Kittrell (ORCID: https://orcid.org/0009-0001-3359-7750)
- Lili Chan (ORCID: https://orcid.org/0000-0003-4300-5760)
- Mayte Suárez‐Fariñas (ORCID: https://orcid.org/0000-0001-8712-3553)
- Ankit Sakhuja (ORCID: https://orcid.org/0000-0002-2045-518X)
- Roopa Kohli‐Seth (ORCID: https://orcid.org/0000-0002-6082-1359)
- Ira S. Hofer (ORCID: https://orcid.org/0000-0001-7456-6697)
- Alexander W. Charney (ORCID: https://orcid.org/0000-0001-8135-6858)
- Monica Kraft (ORCID: https://orcid.org/0000-0003-2626-2183)
- Gagan Kumar (ORCID: https://orcid.org/0000-0002-6024-1055)
- John Oropello (ORCID: https://orcid.org/0000-0003-4467-3584)
Institutions
- West Virginia University (US)
- Emory University (US)
- Chulalongkorn University (TH)
- University of Pittsburgh (US)
- King Chulalongkorn Memorial Hospital (TH)
- West Virginia University Hospitals (US)
- Mount Sinai Hospital (US)
- Northeast Georgia Medical Center (US)
- Pulmonary and Allergy Associates (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/cce.0000000000001354
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00