Hypoxia-preconditioned hUCMSCs protect frozen-thawed human ovarian tissue by modulating the HIF-1α/VEGF pathway
This in vitro study showed that co-culture of ovarian tissue with H-MSCs provides stronger protection than N-MSCs. This effect likely involves the HIF-1α/VEGFA pathway, with enhanced pro-angiogenic signaling, reduced apoptosis and oxidative stress, and preservation of the follicular reserve.
Authors
- Fang Jin (ORCID: https://orcid.org/0000-0001-7795-2593)
- Yanglu Li
- Xiangyan Ruan (ORCID: https://orcid.org/0000-0001-7777-247X)
- Yanqiu Li (ORCID: https://orcid.org/0009-0001-1119-0685)
- Juan Du (ORCID: https://orcid.org/0009-0001-0314-630X)
- Yinmei Dai
- Muqing Gu
- Jiaojiao Cheng
- Alfred Otto Mueck
Institutions
- Capital Medical University (CN)
- Women's Health Research Institute (CA)
- Beijing Obstetrics and Gynecology Hospital (CN)
- University of Tübingen (DE)
Publication Details
- Journal
- Gynecological Endocrinology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1080/09513590.2025.2597612
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00