Contribution of xpert MTB/RIF assay and Urine LF-LAM for the diagnosis of tuberculosis in children aged 5 – 14 years, at selected health facilities in Ethiopia, 2016 – 2019
Pulmonary TB diagnosis was greatly improved with the use of Xpert MTB/RIF assay, particularly in children aged 5-9 years and C/ALHIV who typically have difficulty producing good quality sputum. Urine LF-LAM performed well in children/adolescents who tested positive for HIV, but it performed poorly in the other variables, which suggests that urine LF-LAM testing did not play a critical role in TB diagnosis in children with negative HIV status.
Authors
- Getu Diriba (ORCID: https://orcid.org/0000-0002-0166-682X)
- Muluwork Getahun (ORCID: https://orcid.org/0000-0003-3407-983X)
- Waganeh Sinshaw (ORCID: https://orcid.org/0000-0002-6212-4055)
- Kassahun Denekew Belachew
- Ayinalem Alemu (ORCID: https://orcid.org/0000-0001-5307-8774)
- Mengistu Tadesse (ORCID: https://orcid.org/0000-0001-9390-0355)
- Ephrem Tesfaye (ORCID: https://orcid.org/0000-0001-8859-1906)
- Yenew Kebede (ORCID: https://orcid.org/0000-0001-7224-8628)
- Ameha Mekasha
- Beniam Feleke (ORCID: https://orcid.org/0000-0003-4461-7750)
- Hilina Molalegn
Institutions
- Ethiopian Public Health Institute (ET)
- Centers for Disease Control and Prevention (UG)
- Africa Centres for Disease Control and Prevention (ET)
- Tikur Anbessa Hospital (ET)
- University of Gondar (ET)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1371/journal.pone.0338557
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00