Left ventricular deformation and tissue characteristics in hypertrophic cardiomyopathy patients with HFpEF: a CMR study
HCM patients with HFpEF exhibit both systolic and diastolic dysfunction, accompanied by increased diffuse and focal fibrosis. Independent predictors of HFpEF include lower LV-eGLSr, higher segmental ECV, atrial fibrillation, and drinking. The H<sub>2</sub>FPEF score shows significant associations with tissue-level abnormalities, highlighting the complementary role of CMR-derived strain and tissue characterization in the early detection and risk stratification of HFpEF in HCM.
Authors
- Qiuyi Cai (ORCID: https://orcid.org/0000-0002-5958-5467)
- Zhengkai Zhao
- Xin Peng (ORCID: https://orcid.org/0000-0002-6892-7318)
- Hui Liu (ORCID: https://orcid.org/0000-0001-5227-3164)
- Yuheng Huang (ORCID: https://orcid.org/0009-0000-2890-2442)
- Zhuoan Li
- Jiangyu Tian
- Huaibi Huo (ORCID: https://orcid.org/0000-0001-8619-9302)
- Jian Liu (ORCID: https://orcid.org/0000-0001-5791-7221)
- Yao Song (ORCID: https://orcid.org/0000-0003-0025-795X)
- Jin Gao (ORCID: https://orcid.org/0000-0002-9751-7529)
Institutions
- Shanxi Medical University (CN)
- Purdue University West Lafayette (US)
- Liaoning University of Traditional Chinese Medicine (CN)
- Shaanxi Provincial People's Hospital (CN)
- Third People's Hospital of Chengdu (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- First Hospital of China Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- China Medical University (CN)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12880-025-02110-4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00