IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial Epithelium
IL-13 does not modify viral load or interferon induction but selectively suppresses epithelial antiviral effector programs and enhances secondary inflammatory pathways during RV infection. These findings provide mechanistic insight into how T2 inflammation contributes to viral-triggered asthma morbidity.
Authors
- Teal S. Hallstrand (ORCID: https://orcid.org/0000-0002-5059-6872)
- Nyssa B. Samanas (ORCID: https://orcid.org/0000-0002-6593-1290)
- Weston T. Powell (ORCID: https://orcid.org/0000-0002-1555-1425)
- Gail H. Deutsch (ORCID: https://orcid.org/0000-0002-0571-0285)
- Basilin Benson (ORCID: https://orcid.org/0000-0002-2473-5939)
- Kourtnie Whitfield
- Elizabeth R. Vanderwall (ORCID: https://orcid.org/0000-0002-5684-3694)
- Maria P. White
- Steven F. Ziegler (ORCID: https://orcid.org/0000-0003-0657-5529)
- Matthew C. Altman (ORCID: https://orcid.org/0000-0002-1784-8505)
- Lucille M. Rich (ORCID: https://orcid.org/0000-0001-8109-1028)
- Naresh Doni Jayavelu (ORCID: https://orcid.org/0000-0001-5613-0830)
- Jason S. Debley (ORCID: https://orcid.org/0000-0001-6438-9535)
- Camille Gates
- Patricia C. dela Cruz (ORCID: https://orcid.org/0009-0004-3333-7213)
Institutions
- Seattle Children's Hospital (US)
- Virginia Mason Medical Center (US)
- Children’s Institute (US)
- University of Washington (US)
- Seattle Children's Hospital (US)
- Benaroya Research Institute
- Mississippi Valley State University (US)
- Washington State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-08
- DOI
- https://doi.org/10.64898/2025.12.06.692776
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00