Outcomes and recurrence pattern analysis of intensity modulated chemoradiotherapy in nasopharyngeal cancer: a retrospective study from Heidelberg University Hospital
IMRT with weekly cisplatin yields excellent survival and locoregional control with acceptable toxicity in NPC. Distant metastasis as one of the predominant failure patterns highlights the need for more effective systemic therapies. Most local recurrences arose within high-dose areas, suggesting a potential opportunity for treatment optimization.
Authors
- Maximilian Deng (ORCID: https://orcid.org/0000-0003-4925-7600)
- Sebastian Regnery (ORCID: https://orcid.org/0000-0002-6820-884X)
- Philipp Schröter
- Kristin Lang (ORCID: https://orcid.org/0000-0002-5355-3173)
- Nils Netzer (ORCID: https://orcid.org/0000-0001-5805-0535)
- Henrik Franke
- Thomas Held (ORCID: https://orcid.org/0000-0002-3913-4693)
- Lukas Bauer (ORCID: https://orcid.org/0009-0000-7711-934X)
- Rubens Thölken (ORCID: https://orcid.org/0000-0001-9290-8427)
- Katharina Weusthof (ORCID: https://orcid.org/0000-0002-7307-484X)
- Florian Stritzke (ORCID: https://orcid.org/0000-0001-5099-3221)
- Jürgen Debus
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s13014-025-02769-7
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00