Two Molecular Subgroups Predict Most Recurrences in Advanced Laryngeal Squamous Cell Carcinoma
We demonstrate that VEGF-A has prognostic value in laryngeal carcinoma only when assessed at tumor depth. Alongside a distinct high-risk miRNA signature, we define two molecular subgroups accounting for most recurrences, highlighting the clinical importance of spatial heterogeneity in biomarker evaluation.
Authors
- Silva Kyurkchiyan (ORCID: https://orcid.org/0000-0001-7536-2442)
- Tzvetomir Marinov (ORCID: https://orcid.org/0000-0002-8540-9600)
- Lazar Dimitrov (ORCID: https://orcid.org/0009-0003-8053-8635)
- Gergana Stancheva (ORCID: https://orcid.org/0000-0003-4359-9618)
- Boryana Ilcheva (ORCID: https://orcid.org/0009-0001-0828-1797)
- T. Popov (ORCID: https://orcid.org/0000-0002-8205-3573)
- Albena D. Fakirova (ORCID: https://orcid.org/0009-0008-3120-6948)
- Sylvia Skelina (ORCID: https://orcid.org/0000-0003-2169-4999)
- Radka Kaneva (ORCID: https://orcid.org/0000-0002-1437-1393)
- Veronika Petkova (ORCID: https://orcid.org/0000-0002-2905-8084)
- Stoyan Dimitrov (ORCID: https://orcid.org/0000-0001-6769-3268)
Institutions
- Medical University of Sofia (BG)
- Military Medical Academy (BG)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0249
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00