Mapping of Phospholipase A2 Receptor Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles

Based on the PLA2R yeast surface display system, we identified three new antigen epitopes of PLA2R in membranous nephropathy. The epitope profiles of PLA2R were associated with disease severity and prognosis of membranous nephropathy.

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Publication Details

Journal
Journal of the American Society of Nephrology
Published
2025-12-08
DOI
https://doi.org/10.1681/asn.0000000962
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
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article

Mapping of Phospholipase A2 Receptor Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles

Linqi Zhang, Gang Chen, Xuewang Li, Haoyuan Cui et al.
Journal of the American Society of Nephrology
Renal Diseases and Glomerulopathies
article

Mapping of Phospholipase A2 Receptor Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles

Linqi Zhang, Gang Chen, Xuewang Li, Haoyuan Cui, Peng Xia, Ke Zheng, Yanan Liu, Yangzhong Zhou, Sanxi Ai, Junxian Hong, Ruoke Wang, Peng Chen, Xuemei Li, Yan Qin, Zhiqiang Gao, Xuanling Shi
article en

Abstract

Based on the PLA2R yeast surface display system, we identified three new antigen epitopes of PLA2R in membranous nephropathy. The epitope profiles of PLA2R were associated with disease severity and prognosis of membranous nephropathy.

Journal of the American Society of Nephrology
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN), Tsinghua University (CN)
Openalex Percentile: Top 51%
Renal Diseases and Glomerulopathies
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