Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability
Consistent with cascade models of neurovascular aging, cerebral arterial stiffening was found to partially explain the effect of increasing age on frontal GM volume, even in this highly age-restricted and high functioning cohort. This effect was only significant over the left prefrontal cortex, consistent with greater vulnerability of frontal brain and associated cognitive functions. It was also exclusively present in females, who had better cardiovascular health, larger grey matter volume and greater arterial elasticity than males. These findings are consistent with pulse-DOT measures of cerebral arterial elasticity being more sensitive to subclinical brain structural variability.
Authors
- Frini Karayanidis (ORCID: https://orcid.org/0000-0002-3317-9954)
- Gabriele Gratton (ORCID: https://orcid.org/0000-0003-3634-7463)
- Monica Fabiani (ORCID: https://orcid.org/0000-0002-7579-2773)
- Patricia T. Michie (ORCID: https://orcid.org/0000-0002-4169-8519)
- Sarah H. Johnson (ORCID: https://orcid.org/0000-0001-7412-5322)
- Ashleigh E. Smith (ORCID: https://orcid.org/0000-0001-6316-2259)
- Kathy A. Low (ORCID: https://orcid.org/0000-0001-6787-3701)
- Bryan Paton (ORCID: https://orcid.org/0000-0001-6777-5001)
- Daniel Barker
- J. D. Johnson
- Nicholas Ware
- Christian Behler
Institutions
- University of Illinois Urbana-Champaign (US)
- University of South Australia (AU)
- Newcastle College (GB)
- Hunter Medical Research Institute (AU)
- Cure Brain Cancer Foundation (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-08
- DOI
- https://doi.org/10.64898/2025.12.03.691980
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00