Rare Variants of Immune-Related Genes Increase Susceptibility to Autoimmune Encephalitis: An Association Study

Our findings suggest that RDVs in specific immunological pathways, particularly the T cell receptor signaling pathway, may play a role in AE pathogenesis. The significant associations of <i>PDK1</i>, <i>CAT</i>, and <i>MIA</i> with AE highlight potential genetic contributors to the disease. Further functional studies are necessary to validate these associations and explore their biological relevance, potentially paving the way for improved understanding and future therapeutic targets in AE.