Injections of Autologous Platelet-Rich Plasma into the Facial Skin: Assessing Safety and Influence on the Immune System According to the Routine Laboratory Tests

Abstract Aims: The purpose of this research was to study the safety of the PRP injections into the facial skin and assess its effect on immune system according to the routine laboratory tests. Subjects and Material: The research involved 50 women aged 20 to 52 years who received intradermal PRP injections into the facial skin. General examination, complete blood count before the procedure, and 1, 3, and 6 months after it, rheumatoid factor, lupus anticoagulant, and D-dimer in the blood serum before the procedure and 6 months after it were conducted for all the subjects involved in the research. Results: According to the studied indicators of autoimmune diseases (rheumatoid factor and lupus anticoagulant), there were no differences 6 months after the PRP injection procedure ( P = 0.139 and P = 0.208, respectively). A small number of patients (6–20%) had a slight increase in lymphocytes (up to a maximum of 47.8%) and monocytes (up to a maximum of 11.4%) in the blood after 1, 3, and 6 months, which tended to normalise over time ( P = 0.0001). No undesirable local or systemic reactions after the procedure as well as during the observed period were recorded. Conclusion: An algorithm for laboratory examination of patients before and after the PRP injections into the facial skin was proposed to exclude undesirable adverse reactions after the procedure. The safety research should be continued, taking into account the multiplicity of the procedure and its combination with other cosmetic effects.