Transforming nanoproteomics into multidimensional Raman spectromics for ovarian cancer diagnosis
In briefWe introduce an SiO 2 @Au nanoparticleprotein corona (NPC) array sensor that converts nanoproteomics data into multidimensional Raman spectral fingerprints for ovarian cancer diagnosis.By integrating DNA-Cy3 and Raman dyes, the sensor generates a robust SERS fingerprint with 26 resolvable peaks, circumventing spectral overlap from serum proteins.This method leverages cancer-specific proteomic signatures in NPC, without mass spectrometry, offering an explainable, rapid, and costeffective alternative to traditional proteomic workflows for ovarian cancer detection.
Authors
- Jianqing Zhu (ORCID: https://orcid.org/0000-0001-5736-7397)
- Qiqi Liu (ORCID: https://orcid.org/0000-0001-7677-9901)
- Qimanguli Saiding (ORCID: https://orcid.org/0000-0003-2783-5991)
- Haoxiang Guo (ORCID: https://orcid.org/0000-0002-6481-7154)
- Baichuan Jin
- Jinlong Fan
- Mengjie Wang (ORCID: https://orcid.org/0000-0003-3637-4787)
- Wei Tao (ORCID: https://orcid.org/0000-0002-4277-3728)
- Haobing Guo
- Yuan Liu (ORCID: https://orcid.org/0009-0006-0515-1811)
- Xin Dai (ORCID: https://orcid.org/0000-0002-2811-2616)
Institutions
- Qingdao University (CN)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Tianjin University (CN)
- Zhejiang Cancer Hospital (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Institute of Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cell Biomaterials
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1016/j.celbio.2025.100275
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province