The impact of radical hepatectomy on prognosis of patients with hepatic alveolar echinococcosis complicated with microvascular invasion

To investigate the effect of radical hepatectomy on the prognosis of patients with hepatic alveolar echinococcosis (HAE) complicated with microvascular invasion (MVI). HAE patients who underwent radical hepatectomy at the Echinococcosis Diagnosis and Treatment Center of Qinghai Provincial People's Hospital from January 2014 to December 2020 were collected in this study according to the inclusion and exclusion criteria. The clinical data of the patients were collected and analyzed. According to the surgical method, the patients were divided into anatomical hepatectomy group (Anatomical group) and non-anatomical hepatectomy group (Non-anatomical group). Kaplan-Meier survival analysis was used to compare the 5-year recurrence-free survival (RFS) between the two groups. A total of 375 patients were enrolled in the study (with 185 in Anatomical group and 190 in Non-anatomical group). The results of clinicopathological data analysis showed that compared with the Non-anatomical group, the patients in the Anatomical group had less intraoperative blood loss and blood transfusion, and a lower postoperative recurrence rate (all P < 0.05). The survival analysis results showed that the overall survival of the enrolled patients was 92.9%. Compared with the Non-anatomical group, the 5-year RFS of the Anatomical group was higher (98% vs. 87.7%, P < 0.05). Besides, In the Anatomical group, the 5-year RFS of patients with negative MVI was better than that of patients with positive MVI (100% vs. 94.5%, P < 0.05). Similarly, in the Non-anatomical group, the 5-year RFS of patients with negative MVI was also superior to that of patients with positive MVI (99% vs. 75.8%, P < 0.05). In addition to surgical methods, MVI may be another important factor affecting the 5-year RFS of patients with HAE.