9-Oxo-2-(p-tolyl)-4,9-dihydropyrazolo[5,1-b]quinazoline-3a(3H)-carboxylic Acid

Compounds based on the pyrazoloquinazoline scaffold are of significant interest in synthetic organic chemistry owing to their potential biological activity. In this work, we describe the synthesis of a new derivative with this scaffold, 9-oxo-2-(p-tolyl)-4,9-dihydropyrazolo[5,1-b]quinazoline-3a(3H)-carboxylic acid, obtained by reacting 2,4-dioxo-4-(p-tolyl)butanoic acid with 2-aminobenzohydrazide in a 1:1 ratio when mixed in ethanol. The compound was characterized by 1H/13C NMR, IR, and X-ray diffraction analysis.

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Publication Details

Journal
Molbank
Published
2025-12-08
DOI
https://doi.org/10.3390/m2105
Primary Topic
Quinazolinone synthesis and applications
Type
article
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article

9-Oxo-2-(p-tolyl)-4,9-dihydropyrazolo[5,1-b]quinazoline-3a(3H)-carboxylic Acid

Anastasia A. Andreeva, А. Н. Масливец, Yurii V. Shklyaev
Molbank
Quinazolinone synthesis and applications
article

9-Oxo-2-(p-tolyl)-4,9-dihydropyrazolo[5,1-b]quinazoline-3a(3H)-carboxylic Acid

Anastasia A. Andreeva, А. Н. Масливец, Yurii V. Shklyaev
article en

Abstract

Compounds based on the pyrazoloquinazoline scaffold are of significant interest in synthetic organic chemistry owing to their potential biological activity. In this work, we describe the synthesis of a new derivative with this scaffold, 9-oxo-2-(p-tolyl)-4,9-dihydropyrazolo[5,1-b]quinazoline-3a(3H)-carboxylic acid, obtained by reacting 2,4-dioxo-4-(p-tolyl)butanoic acid with 2-aminobenzohydrazide in a 1:1 ratio when mixed in ethanol. The compound was characterized by 1H/13C NMR, IR, and X-ray diffraction analysis.

MolbankVol. 2025(4)
Perm State University (RU), Institute of Technical Chemistry (RU)
Openalex Percentile: Top 71%
Quinazolinone synthesis and applications
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