Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF <sub>2</sub> H as transmetalation reagent

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF<sub>2</sub>H as CF<sub>2</sub>H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating <i>inter alia</i> synthetically valuable triflates.

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Publication Details

Journal
Chemical Communications
Published
2025-12-08
DOI
https://doi.org/10.1039/d5cc06479a
Primary Topic
Fluorine in Organic Chemistry
Type
article
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article

Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF 2 H as transmetalation reagent

Torben Rogge
Chemical Communications
Fluorine in Organic Chemistry
article

Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF 2 H as transmetalation reagent

Torben Rogge
article en

Abstract

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF<sub>2</sub>H as CF<sub>2</sub>H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating <i>inter alia</i> synthetically valuable triflates.

Chemical CommunicationsVol. 62(4)
Technische Universität Berlin (DE)
Openalex Percentile: Top 68%
Fluorine in Organic Chemistry
DOIOpen Access PDFOpenAlex
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Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF <sub>2</sub> H as transmetalation reagent — Torben Rogge · Chemical Communications (2025) | TGRS Research Map | TGRS