Rare Localization of Extramammary Paget’s Disease in the Axilla: A Case Report and Literature Review

Extramammary Paget's disease is a rare malignant tumor that frequently presents in areas rich in apocrine glands, most often affecting the skin of the perianal area: the labia minora, clitoris, scrotum, penis, skin of the lower abdomen, and inguinal folds. Tumors localized outside the perianal region are relatively rare. We present a clinical case of a 70-year-old patient with a tumor localized on the skin of the right axillary region, with clinical, histological, and immunohistochemical characteristics. The diagnosis of extramammary Paget's disease with atypical localization is relatively difficult to reach in time, as tumors are often mistakenly considered as inflammatory skin lesions, and the appropriate treatment may therefore be delayed.

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Publication Details

Journal
Journal of Clinical Medicine
Published
2025-12-03
DOI
https://doi.org/10.3390/jcm14238581
Primary Topic
Cancer and Skin Lesions
Type
article
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article

Rare Localization of Extramammary Paget’s Disease in the Axilla: A Case Report and Literature Review

Valentina A. Kudryashova, Maria Kharitonova, С.В. Пирожков, V. A. Smolyannikova et al.
Journal of Clinical Medicine
Cancer and Skin Lesions
article

Rare Localization of Extramammary Paget’s Disease in the Axilla: A Case Report and Literature Review

Valentina A. Kudryashova, Maria Kharitonova, С.В. Пирожков, V. A. Smolyannikova, Marina N. Vukolova, Marina Krot, Yu. A. Lutokhina, A. I. Mordovina, Andrey V. Filatov, Olga A. Gafurova
article en

Abstract

Extramammary Paget's disease is a rare malignant tumor that frequently presents in areas rich in apocrine glands, most often affecting the skin of the perianal area: the labia minora, clitoris, scrotum, penis, skin of the lower abdomen, and inguinal folds. Tumors localized outside the perianal region are relatively rare. We present a clinical case of a 70-year-old patient with a tumor localized on the skin of the right axillary region, with clinical, histological, and immunohistochemical characteristics. The diagnosis of extramammary Paget's disease with atypical localization is relatively difficult to reach in time, as tumors are often mistakenly considered as inflammatory skin lesions, and the appropriate treatment may therefore be delayed.

Journal of Clinical MedicineVol. 14(23)
Sechenov University (RU), State Research Center for Dermatovenereology and Cosmetology (RU)
Openalex Percentile: Top 38%
Cancer and Skin Lesions
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