Transcriptomic profiles of human parthenogenotes: contribution of the maternal genome across the early embryo development
This study provides the first comprehensive single-cell transcriptomic characterization of early human parthenogenotes, suggesting a structured, genome-driven maternal program that governs early embryonic development in the absence of paternal input. The identification of key TFs and MEG signature highlights the pivotal regulatory role of the maternal genome before EGA and may inform strategies to improve outcomes in assisted reproductive technologies.
Authors
- Roberto González-Martín (ORCID: https://orcid.org/0000-0002-1264-5362)
- María-José Escribá (ORCID: https://orcid.org/0000-0002-1321-4978)
- Laura Escrich (ORCID: https://orcid.org/0000-0001-5772-4462)
- Alicia Quiñonero (ORCID: https://orcid.org/0009-0000-7286-5757)
- Arancha Galán
- Pedro de Castro (ORCID: https://orcid.org/0000-0002-7879-3528)
- Francisco Domı́nguez (ORCID: https://orcid.org/0000-0002-7620-8081)
- Xavier Vendrell (ORCID: https://orcid.org/0000-0001-7403-3372)
- Noelia Grau
Institutions
- Valencian Infertility Institute (ES)
- Sistemas Genómicos (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- F&S Science
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1016/j.xfss.2025.12.003
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00