Reconstitution of CFTR ubiquitination identifies lysine-420 as a regulator of cell surface residence and current
We establish a system in which residue-specific modifications of CFTR by any component of the ubiquitin machinery can now be surveyed.
Authors
- Jeffrey L. Brodsky (ORCID: https://orcid.org/0000-0002-6984-8486)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Fan Jiang (ORCID: https://orcid.org/0000-0001-7015-1232)
- Eric J. Sorscher (ORCID: https://orcid.org/0000-0001-9341-3354)
- John C. Kappes (ORCID: https://orcid.org/0000-0002-7586-2815)
- Zhengrong Yang (ORCID: https://orcid.org/0000-0002-8981-9105)
- Jennifer L. Goeckeler-Fried (ORCID: https://orcid.org/0000-0001-5940-9917)
- Jeong S. Hong (ORCID: https://orcid.org/0000-0003-4719-1855)
- Disha Joshi (ORCID: https://orcid.org/0009-0006-3840-4993)
Institutions
- University of Pittsburgh (US)
- University of Alabama at Birmingham (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102393
- Citations
- 1
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 1.15