Tegileridine for moderate-to-severe acute pain following abdominal surgery: A randomized, double-blind, phase 3 clinical trial
Tegileridine is a biased μ-opioid receptor agonist that selectively activates the G protein pathway, designed to provide analgesia with fewer opioid-related adverse effects. In this phase 3 study, 526 patients with postoperative pain after abdominal surgery were randomized and received placebo, tegileridine at 0.75 mg, tegileridine at 1.0 mg, or morphine. For the primary outcome of effective analgesia, the mean (SD) summed pain intensity difference at rest over the first 24 h from time 0 (SPID<sub>24</sub>) scores are -61.15 (28.25) and -68.98 (30.33) for the 0.5 and 0.75 mg doses of tegileridine, respectively, compared with -49.63 (29.35) in the placebo group (all p < 0.001) and -71.16 (34.76) in the morphine group. The total pain relief scores (mean [SD]) at 24 h were 58.76 (21.79) with 0.75 mg tegileridine and 61.95 (18.94) with 1.0 mg tegileridine, compared with 47.56 (21.00) with placebo and 59.09 (19.34) with morphine. In summary, tegileridine provides effective analgesia that was significantly superior to placebo and comparable to morphine.
Authors
- Xiangdong Chen (ORCID: https://orcid.org/0000-0003-3347-2947)
- Jianbo Yu (ORCID: https://orcid.org/0000-0003-3204-2486)
- Haihui Xie (ORCID: https://orcid.org/0000-0001-7406-8268)
- Jinghua Ren (ORCID: https://orcid.org/0009-0009-4137-0191)
- Yonghao Yu (ORCID: https://orcid.org/0000-0001-8414-4666)
- Ju Gao (ORCID: https://orcid.org/0000-0001-7063-7574)
- Shuchun Yu (ORCID: https://orcid.org/0000-0002-4435-8034)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-5354-5106)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-9100-3447)
- Jiaqiang Zhang (ORCID: https://orcid.org/0000-0002-4329-784X)
- Yafeng Wang (ORCID: https://orcid.org/0000-0002-8994-4846)
- Zhengyuan Xia (ORCID: https://orcid.org/0000-0002-7002-5524)
- Liang Ge (ORCID: https://orcid.org/0000-0001-7619-1278)
- Mingjun Xu (ORCID: https://orcid.org/0000-0001-5585-7712)
- Wanwei Jiang
- He Huang (ORCID: https://orcid.org/0000-0002-1498-9871)
- Hexin Gao
- Yanjuan Huang
- Yangwen Ou
- Ping Zhao
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Guangdong Medical College (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Jilin University (CN)
- Tianjin Medical University General Hospital (CN)
- Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region (CN)
- Tianjin Nankai Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Dongguan People’s Hospital (CN)
- First Hospital of Jilin University (CN)
- Wuhan Union Hospital (CN)
- Henan Provincial People's Hospital (CN)
- The Second Nanning People's Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
- Second People’s Hospital of Yibin (CN)
- Third Xiangya Hospital (CN)
- Union Hospital (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Tianjin Medical University (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
- University of Hong Kong (HK)
- China Medical University (CN)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.xcrm.2025.102477
- Citations
- 1
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 2.01