The Role of Autophagy Genes in Energy-Related Disorders

Autophagy is a cellular catabolic mechanism that facilitates the degradation of cytoplasmic components, thereby restoring energy homeostasis and mitigating cellular damage. This process functions as a housekeeping system, essential for maintaining organismal viability under stressful conditions. Numerous studies have highlighted the role of autophagy in regulating various physiological processes, including metabolic pathways. Notably, certain autophagy-related genes may play a relevant role in metabolic disorders, extending beyond their involvement in the autophagic process, and may offer potential therapeutic avenues for treating energy-related metabolic diseases. This review summarizes the roles of various components of each autophagic complex and the regulators involved in the autophagic process. In particular, it explores the intricate relationship between autophagy and several metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, and non-alcoholic fatty liver disease (NAFLD).

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Publication Details

Journal
Cells
Published
2025-12-08
DOI
https://doi.org/10.3390/cells14241947
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
0.00

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article

The Role of Autophagy Genes in Energy-Related Disorders

Noemí Cárdenas Rodríguez, Daniel Ortega-Cuéllar, Beatriz Hernández‐Ochoa, Asdrúbal Aguilera‐Méndez et al.
Cells
Autophagy in Disease and Therapy
article

The Role of Autophagy Genes in Energy-Related Disorders

Noemí Cárdenas Rodríguez, Daniel Ortega-Cuéllar, Beatriz Hernández‐Ochoa, Asdrúbal Aguilera‐Méndez, Saúl Gómez‐Manzo, Luis Miguel Canseco‐Ávila, Cindy Bandala, Luz Camacho, Berenice Franco-Juárez
article en

Abstract

Autophagy is a cellular catabolic mechanism that facilitates the degradation of cytoplasmic components, thereby restoring energy homeostasis and mitigating cellular damage. This process functions as a housekeeping system, essential for maintaining organismal viability under stressful conditions. Numerous studies have highlighted the role of autophagy in regulating various physiological processes, including metabolic pathways. Notably, certain autophagy-related genes may play a relevant role in metabolic disorders, extending beyond their involvement in the autophagic process, and may offer potential therapeutic avenues for treating energy-related metabolic diseases. This review summarizes the roles of various components of each autophagic complex and the regulators involved in the autophagic process. In particular, it explores the intricate relationship between autophagy and several metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, and non-alcoholic fatty liver disease (NAFLD).

CellsVol. 14(24)
Universidad Michoacana de San Nicolás de Hidalgo (MX), Secretaria de Salud (MX), Hospital Infantil de México Federico Gómez (MX), Universidad Autónoma de Chiapas (MX), Instituto Nacional de Pediatria (MX), Instituto Nacional de Neurología y Neurocirugía (MX), Instituto Politécnico Nacional (MX), Universidad Nacional Autónoma de México (MX)
Instituto Nacional de Pediatria
Openalex Percentile: Top 50%
Autophagy in Disease and Therapy
DOIOpen Access PDFOpenAlex
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