Development of a New Generation Water-Soluble Photosensitizer Based on Chlorin e6 with Platinum

The interaction between platinum (Pt) and Chlorin e6 in aqueous solutions has been studied using luminescence and electron spectroscopic techniques. The potential for singlet oxygen formation and photodegradation of Chlorin e6 in the presence of platinum under red light has been investigated. It has been found that an aqueous solution of Chlorin e6 with platinum exhibits photodynamic activity, generating singlet oxygen more intensely than a solution of Chlorin e6 alone. Effective cell death has been observed in tumor cells of the Ehrlich ascites adenocarcinoma after one day of exposure to the Chlorin e6-Pt complex. A solution with a 1 : 0.5 molar ratio of Chlorin e6 to Pt has been identified as a promising candidate for a water-soluble anticancer agent with combined photodynamic and chemotherapeutic effects.