The profiling of extracellular vesicle subtypes in Huntington’s disease brains identifies Alix as a novel marker of neuropathology
These findings highlight disease-specific changes in EV populations and cargo in HD, and identify Alix as a potential neuropathological marker. This study advances our understanding of the role of brain-derived EVs in HD and underscores their potential utility in biomarker discovery.
Authors
- Anna Vázquez‐Oliver (ORCID: https://orcid.org/0000-0002-9842-7656)
- Jesús Pérez‐Pérez (ORCID: https://orcid.org/0000-0002-9835-0484)
- Samanta Ortuño‐Miquel (ORCID: https://orcid.org/0000-0003-0731-6975)
- Esther Pérez‐Navarro (ORCID: https://orcid.org/0000-0001-9165-6539)
- Eduard Sabidó (ORCID: https://orcid.org/0000-0001-6506-7714)
- Marta García-Forn (ORCID: https://orcid.org/0000-0003-3505-1003)
- Saül Martínez‐Horta (ORCID: https://orcid.org/0000-0003-0125-7249)
- Jaime Kulisevsky (ORCID: https://orcid.org/0000-0003-4870-1431)
- Frederic Sampedro (ORCID: https://orcid.org/0000-0002-3933-1355)
- Elisa Rivas‐Asensio
- Nil Salvat‐Rovira
- Eva Borràs (ORCID: https://orcid.org/0000-0001-5100-7809)
- María Sánchez-Carcelén
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Neurociencias (ES)
- Departament de Salut (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Centre for Genomic Regulation (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s40478-025-02187-6
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91