Sodium Hypophosphite Assisted Ruthenium Catalyzed Reductive Amination under Mild Conditions
We report a catalytic method for reductive amination using sodium hypophosphite as a cheap, bulk-grade available, and environmentally friendly reductant. The use of CpRu(PPh<sub>3</sub>)<sub>2</sub>Cl allowed the reaction to proceed under mild conditions, affording products in preparative yields. The method demonstrated great tolerance for a wide range of functional groups. A set of mechanistic trials resulted in one of the possible catalytic species, the Ru-hydride complex, being identified by NMR. A plausible mechanism of the process was proposed.
Authors
- Evgenii I. Gutsul (ORCID: https://orcid.org/0000-0002-2835-4674)
- Oleg I. Afanasyev (ORCID: https://orcid.org/0000-0002-6224-6407)
- Fedor S. Kliuev (ORCID: https://orcid.org/0000-0002-9712-6085)
- O. V. Zvereva
- Evgeniya Podyacheva (ORCID: https://orcid.org/0000-0002-0228-9261)
- Denis Chusov (ORCID: https://orcid.org/0000-0001-6770-5484)
- Nadezhda I. Lebedeva
Institutions
- National Research University Higher School of Economics (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04073
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00