Hepatic Metastasis From Duodenal Ampullary Carcinoma With Intense FAP Activity But Without FDG Uptake
A 58-year-old man with 3 years postduodenal ampullary carcinoma surgery underwent a routine abdominal CT 1 week ago, revealing occupancy of the S7 segment of the liver, suggesting a probability of metastasis. Serum CA19-9 and CEA levels were within the reference range. The patient, with informed consent, was then enrolled in a clinical trial of comparison of 18 F-FDG and 68 Ga-FAPI-04 PET/CT in hepatic lesions. Compared with the absence of tracer uptake on 18 F-FDG PET/CT, 18 Ga-FAPI-04 PET/CT showed high tracer uptake and prominent tumor-to-background contrast. The final pathology confirmed an infiltrating adenocarcinoma, originating from the primary duodenal ampullary carcinoma.
Authors
- Yujing Hu (ORCID: https://orcid.org/0000-0001-5739-8732)
- Yanzhu Bian (ORCID: https://orcid.org/0000-0002-5616-7059)
- Lu Zheng (ORCID: https://orcid.org/0000-0002-1619-6525)
- Xiaowei Cai (ORCID: https://orcid.org/0000-0003-2033-617X)
- R. Duan (ORCID: https://orcid.org/0009-0007-3618-1180)
Institutions
- National Natural Science Foundation of China (CN)
- U.S. National Science Foundation (US)
- Hebei General Hospital (CN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1097/rlu.0000000000006191
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00