Role of Histamine in Liver Ischemia-Reperfusion Injury—Implication for H1 Receptor Antagonist in the Clinical Application
Histamine is a key metabolite that exacerbates liver IRI via H1R-mediated signaling pathways. These findings highlight the potential of H1-antihistamines as a promising therapeutic approach for mitigating liver injury associated with liver surgery and liver transplantation.
Authors
- Hiroshi Kawamoto (ORCID: https://orcid.org/0000-0002-7670-9900)
- Hiroaki Terajima (ORCID: https://orcid.org/0000-0001-7938-6345)
- Hirofumi Hirao (ORCID: https://orcid.org/0000-0001-6975-2436)
- Yuki Kidoguchi
- Junya Kawasoe
- Kojiro Taura (ORCID: https://orcid.org/0000-0003-4164-3988)
- Etsuro Hatano (ORCID: https://orcid.org/0000-0003-3407-1918)
- Yoichiro Uchida (ORCID: https://orcid.org/0000-0003-2266-7722)
- Kosuke Tanaka (ORCID: https://orcid.org/0000-0003-4958-4345)
- Shoichi Kageyama (ORCID: https://orcid.org/0000-0002-2398-2428)
- Kojiro Nakamura (ORCID: https://orcid.org/0000-0002-9619-9039)
- Takeshi Watanabe (ORCID: https://orcid.org/0000-0001-7850-4178)
- Masaaki Ito (ORCID: https://orcid.org/0000-0002-1661-9647)
- Kenichi Saga
- Kentaro Kadono
Institutions
- Kyoto University (JP)
- Kitano Hospital (JP)
Publication Details
- Journal
- Transplantation
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1097/tp.0000000000005594
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00