The Diagnostic Reliability of BIN1 and TOMM40 Genotyping in Assessing Dementia Risk
Data on the effects of <i>BIN1</i> rs744373 and <i>TOMM40</i> rs2075650 polymorphisms in MCI and dementia remain limited and inconsistent. In our study, significant differences were observed only for the <i>TOMM40</i> rs2075650 GG genotype and G allele, which were more frequent in Alzheimer's disease patients than in controls. No significant associations were found for MCI, vascular dementia, or mixed dementia, nor for the <i>BIN1</i> rs744373 polymorphism. These results suggest that <i>TOMM40</i> rs2075650 genotyping may serve as an additional marker for assessing AD risk.
Authors
- Elżbieta Trypka (ORCID: https://orcid.org/0000-0001-9280-6930)
- Anna Wiela−Hojeńska (ORCID: https://orcid.org/0000-0003-3813-2300)
- Krystyna Głowacka (ORCID: https://orcid.org/0000-0002-9748-2813)
- Jerzy Leszek (ORCID: https://orcid.org/0000-0002-2316-2470)
- Małgorzata Rąpała (ORCID: https://orcid.org/0000-0002-2789-5911)
- Marta Machowska
- Janusz Piechota
- Aleksandra Mikołajczyk-Tarnawa
Institutions
- Wroclaw Medical University (PL)
- National Quantum Information Centre in Gdansk (PL)
- Trusted Information Consulting (Poland) (PL)
Publication Details
- Journal
- Genes
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3390/genes16121469
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00