Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque
These insights highlight fundamental interspecies and allelic distinctions that are critical for interpreting FcγRIIa-mediated effector functions in macaque models and for optimizing translational antibody and vaccine design.
Authors
- Justin Pollara (ORCID: https://orcid.org/0000-0003-1892-4722)
- Haleigh E. Conley (ORCID: https://orcid.org/0000-0002-6370-6532)
- Xiaoxuan Ge (ORCID: https://orcid.org/0000-0002-0975-4744)
- Madeleine Lee (ORCID: https://orcid.org/0009-0005-5400-4837)
- Marzena Pazgier (ORCID: https://orcid.org/0000-0003-0594-5057)
- Suneetha Gottumukkala
- William D. Tolbert (ORCID: https://orcid.org/0000-0001-7549-9596)
- Margaret E. Ackerman (ORCID: https://orcid.org/0000-0002-4253-3476)
- Marek Korzeniowski (ORCID: https://orcid.org/0000-0002-5264-7303)
- Paula B. Nhan
- Monika Chandravanshi
- Julianna Veilleux
Institutions
- Dartmouth College (US)
- Henry M. Jackson Foundation (US)
- Uniformed Services University of the Health Sciences (US)
- Duke University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1726068
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00