Lung Ultrasound Findings in Pediatric Mycoplasma Pneumoniae Pneumonia: A Prospective Multicenter Pilot Study

<b>Aims:</b> To describe lung ultrasound (LUS) features of <i>Mycoplasma pneumoniae</i> pneumonia and their distribution in pediatric age, and to correlate imaging findings with clinical and laboratory data. <b>Methods:</b> This is a multicenter, prospective, pilot study that involved three hospitals. In total, 35 patients aged 1 month to 17 years, admitted with a diagnosis of <i>Mycoplasma pneumoniae</i> infection, were enrolled. History, clinical, microbiological, and ultrasound data were collected. The LUS examination was performed at admission, recording the following features: presence of subpleural consolidation, bronchograms, B lines, or pleural effusion, and their characteristics. The scans were performed using a standardized approach, in which a composite score was obtained by summing the scores of the different parameters. <b>Results:</b> Consolidations were seen in 97% of children (mostly located in basal, posterior, and lateral fields), and 65% of patients had multiple ones. Non-perilesional B lines were found in 43% of cases, principally in the posterior and basal fields. Pleural effusion was found in 37% of children. The univariate logistic regression showed a correlation between the age of the patient and large-sized consolidations. Moreover, increased lymphocyte count was associated with a lower risk of large-sized consolidations. <b>Conclusions:</b> LUS is a low-cost, non-invasive tool that can reveal findings suggestive of <i>Mycoplasma pneumoniae</i> infection and help physicians better manage children with lower respiratory tract infections, supporting a more personalized diagnostic and therapeutic approach, including antibiotic selection. These preliminary findings also indicate that a larger, comparative study involving other bacterial and viral etiologic agents is warranted to confirm whether LUS patterns are pathogen-specific and whether they can predict clinical outcomes.