Evaluation of sex differences in survival among glioblastoma patients treated with immune checkpoint inhibitors

In nGBM and rGBM, ICI therapy was not associated with sex difference in PFS or OS. Clinically meaningful sex-based outcome differences may be better understood by prospective evaluation in clinical trials.

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Publication Details

Journal
Neuro-Oncology Advances
Published
2025-12-08
DOI
https://doi.org/10.1093/noajnl/vdaf250
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Evaluation of sex differences in survival among glioblastoma patients treated with immune checkpoint inhibitors

Brooke Barlow, L. Nicolas Gonzalez Castro, Loai J. A. Aker, Tamar R. Berger et al.
Neuro-Oncology Advances
Glioma Diagnosis and Treatment
article

Evaluation of sex differences in survival among glioblastoma patients treated with immune checkpoint inhibitors

Brooke Barlow, L. Nicolas Gonzalez Castro, Loai J. A. Aker, Tamar R. Berger, Alona Muzikansky, John Yohan Rhee, Lakshmi Nayak, Patrick Yung Wen, Gilbert Youssef, Aleksandra B Lasica, Thomas Nelson, J Ricardo McFaline-Figueroa, Zhou Lan, Eudocia Q. Lee, Vihang Nakhate, Elisa Aquilanti, Rameen Beroukhim, Ian Pan, Ugonma Nnenna Chukwueke, Alyssa Russ, David A. Reardon, Chibueze D. Nwagwu, Raymond Y. Huang, Tracy T. Batchelor, Albert Jiao, Catharina Westergaard
article en

Abstract

In nGBM and rGBM, ICI therapy was not associated with sex difference in PFS or OS. Clinically meaningful sex-based outcome differences may be better understood by prospective evaluation in clinical trials.

Neuro-Oncology AdvancesVol. 8(1)
Brigham and Women's Hospital (US), Harvard University (US), University of California, San Francisco (US), NYU Langone Health (US), Massachusetts General Hospital (US), Center for Neuro-Oncology (US), Dana-Farber Cancer Institute (US), New York University (US)
Openalex Percentile: Top 40%
Glioma Diagnosis and Treatment
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