Assembly of α-Aryl Sulfones and Allyl Sulfones and Their Amide Analogues via Copper-Catalyzed Coupling Reactions
A method is described for the synthesis of α-aryl and allylic sulfones and sulfonamides through CuBr/oxalamide-catalyzed coupling at 40 °C. This transformation involves coupling with (hetero)aryl or vinyl bromides and 2-substituted sulfonylacetates (or amide analogues), proceeding via spontaneous hydrolysis and decarboxylation. The conditions are compatible with various functional groups and heterocycles, allowing for the diverse syntheses of the target compounds.
Authors
- Dawei Ma (ORCID: https://orcid.org/0000-0002-1721-7551)
- Xuanhao Zhang (ORCID: https://orcid.org/0009-0004-2719-9221)
- Bin Wu (ORCID: https://orcid.org/0000-0002-9761-2139)
- Lanting Xu (ORCID: https://orcid.org/0000-0001-8467-3648)
Institutions
- ShanghaiTech University (CN)
- Novartis (China) (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04490
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00