An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine

Abstract Military‐related burn wounds present unique clinical challenges, including high infection risk, austere treatment environments, and the need for rapid hemostasis. In this study, the study develops a multifunctional PG@PAC powder hydrogel dressing composed of incorporating phenylboronic acid‐modified oxidized dextran (POD), carbonic dihydrazide‐modified gelatin (Gel‐CDH), and the self‐assembly nanoparticles of proanthocyanidins (PA) and chlorhexidine acetate (CHX). Upon contact with wound exudates, the powder rapidly self‐assembled into a robust hydrogel via dynamic Schiff‐base reactions, exhibiting strong tissue adhesion, self‐healing ability, and mechanical properties comparable to natural skin. The PG@PAC (POD/Gel‐CDH@PA/CHX) hydrogel possesses broad‐spectrum antibacterial effects, powerful reactive oxygen species‐scavenging activity, and excellent biocompatibility. It also facilitates macrophage polarization to the M2 phenotype, which lead to the decrease of pro‐inflammatory cytokines and the increase of anti‐inflammatory cytokines. In a murine model with S. aureus ‐infected burn wounds, PG@PAC treatment improves wound microenvironment, resulting in accelerated wound healing, augmented collagen deposition, decreased bacterial burden, and facilitated angiogenesis. These results indicate that PG@PAC is a potential all‐in‐one ready‐to‐use dressing for infected burn wound under resource‐limited environments and provide a promising envision of battlefield wound management.