Toxicology of Heavy Metals in Biological Matrices: A Paradigm Shift From Single-Analyte Measurement to Comprehensive Screening

By providing a holistic view of an individual's elemental profile, the metallomic footprint of their exposome, this approach offers a more complete and clinically relevant picture, capturing not only the toxicant but also the biological context in which it acts. We conclude that quantitative multielement screening is no longer a theoretical possibility but a practical necessity for clinical toxicology to enhance diagnostic accuracy and improve patient outcomes.