Biochemical study on microRNAs (miR-410, miR-133 and miR-582) in Egyptian type 1 diabetic patients

Our findings showed a statistically significant difference in the median relative expression levels of miR-410, miR-133, and miR-582 between the T1DM group and the control group. T1DM patients had higher levels of miR-410 (P < .0001), miR- 133 (P = .006), and miR-582 (P < .0001) compared to controls. ROC curve analysis indicated that miR-410, miR-133, and miR-582 can distinguish T1DM patients from healthy subjects. For miR-410, at a cutoff point of 0.0009, sensitivity was 62%, specificity was 80%, and the area under the curve (AUC) was 0.713. For miR-133, the cutoff was 0.0016, with AUC 0.628, sensitivity 63%, and specificity 60%. For miR-582, the cutoff was 0.00028, with AUC 0.668, sensitivity 71.0%, and specificity 50%.