UBE2M inhibits neoplastic cell proliferation via MKK7–JNK–EGR1 axis in melanoma
This study establishes UBE2M as a critical tumor suppressor in melanoma through the MKK7 neddylation-JNK-EGR1 axis and highlights its potential as a therapeutic target.
Authors
- Xinxing Lyu (ORCID: https://orcid.org/0000-0002-6310-6772)
- Piao Zeng
- Ningning Dang (ORCID: https://orcid.org/0000-0002-2764-4995)
- Shuhong Huang (ORCID: https://orcid.org/0009-0008-8481-5368)
- Yibo Wang (ORCID: https://orcid.org/0000-0003-3633-8276)
- Chenglong Pan (ORCID: https://orcid.org/0000-0002-9861-3459)
- Xiang Lin (ORCID: https://orcid.org/0000-0002-5349-8928)
- Li Ni (ORCID: https://orcid.org/0000-0003-0809-4892)
- Linlin Xu (ORCID: https://orcid.org/0000-0002-5656-0248)
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-07531-x
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00