Au (I)/Ag (I)‐Catalyzed Regio‐ and Stereoselective Synthesis of 5‐Alkylidene‐Pyrrolidin‐2‐ones From Linear Alkynoic Acids and Amines
ABSTRACT Herein, we report the regio‐ and stereoselective synthesis of 5‐alkylidene‐pyrrolidin‐2‐one derivatives through an Ag (I) or Au (I)‐catalyzed cascade reaction between linear alkynoic acids and primary amines. This protocol features excellent regio‐ and stereoselectivity, good functional group tolerance, broad substrate scope, good to high yields, and high bond‐forming efficiency, thus providing an efficient and convenient route to a variety of 5‐alkylidene‐pyrrolidin‐2‐ones.
Authors
- Fei Zhao (ORCID: https://orcid.org/0000-0003-1841-4466)
- Xiuwen Jia (ORCID: https://orcid.org/0000-0002-1126-2677)
- Jun Huang (ORCID: https://orcid.org/0000-0002-6092-4366)
- Pinyi Li
Institutions
- Institute of Agro-Products Processing Science and Technology (CN)
- Chongqing Academy of Animal Science (CN)
- Chengdu University (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/slct.202504630
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Natural Science Foundation of Shandong Province
- Centre Scientifique et Technique du Bâtiment
- Chengdu University
- Shandong Academy of Agricultural Sciences