NVUAtlas: A Comprehensive Single-Nucleus RNA-Seq Resource for the Human Neurovascular Unit in Alzheimer’s Disease
The Human NVU Atlas provides a high-resolution, integrated transcriptomic framework for dissecting the cellular heterogeneity of the neurovascular unit. By uncovering sex-specific vascular mechanisms and disrupted intercellular communication, this resource highlights the critical role of vascular cells in AD progression and serves as a foundational reference for investigating cerebrovascular contribution to AD.
Authors
- Karunya K. Kandimalla (ORCID: https://orcid.org/0000-0001-7786-1915)
- Mikel Hernáez (ORCID: https://orcid.org/0000-0003-0443-2305)
- Xiaojia Tang (ORCID: https://orcid.org/0000-0003-2457-9953)
- Krishna R. Kalari (ORCID: https://orcid.org/0000-0001-8944-8378)
- D. Nelson (ORCID: https://orcid.org/0000-0002-6639-6381)
Institutions
- University of Minnesota (US)
- Mayo Clinic in Florida (US)
- Universidad de Navarra (ES)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-04
- DOI
- https://doi.org/10.64898/2025.12.03.692162
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00