Distinct Myogenic Stages Recapitulate Transcriptomic Networks in COPD Cachexia
These results provide a foundation for using myocytes and myoblasts as <i>in vitro</i> models of degeneration and repair pathway dysregulation in COPD-cachexia. Several modules were preserved between bulk skeletal muscle and HMDC, suggesting HMDC have utility for studying COPD-cachexia.
Authors
- J.W. Chiles (ORCID: https://orcid.org/0000-0002-9935-6319)
- Rakesh P. Patel (ORCID: https://orcid.org/0000-0002-1526-4303)
- Anna Thalacker‐Mercer (ORCID: https://orcid.org/0000-0002-9124-7927)
- Harry B. Rossiter (ORCID: https://orcid.org/0000-0002-7884-0726)
- Merry‐Lynn McDonald (ORCID: https://orcid.org/0000-0002-2647-9422)
- Wenxia Ma (ORCID: https://orcid.org/0000-0001-5605-4241)
- Richard Casaburi (ORCID: https://orcid.org/0000-0002-8851-8589)
- Kaleen M. Lavin (ORCID: https://orcid.org/0000-0003-1426-8174)
- Hanna Sothers (ORCID: https://orcid.org/0000-0002-7757-1843)
- Mohamed Kazamel (ORCID: https://orcid.org/0000-0002-1261-2798)
- J. Michael Wells (ORCID: https://orcid.org/0000-0001-9612-5454)
- Bitota K Lukusa-Sawalena (ORCID: https://orcid.org/0000-0003-1919-7854)
Institutions
- UCLA Medical Center (US)
- University of Alabama at Birmingham (US)
- Pulmonary and Allergy Associates (US)
- Harbor–UCLA Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-05
- DOI
- https://doi.org/10.64898/2025.12.03.692216
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00