Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex
Dopamine and serotonin levels increased following acute DBS to the SCC in humans.Acute dopamine and serotonin changes predicted later mood and response speed changes.Sustained TRD recovery was predicted by acute increases in both dopamine and serotonin estimates.
Authors
- Ayaka Kato (ORCID: https://orcid.org/0000-0002-6306-6600)
- Brian Harris Kopell (ORCID: https://orcid.org/0000-0002-6955-4787)
- Christopher J. Rozell (ORCID: https://orcid.org/0000-0001-5173-1661)
- Xiaosi Gu (ORCID: https://orcid.org/0000-0002-9373-987X)
- Seth R. Batten (ORCID: https://orcid.org/0000-0001-8147-4301)
- Martijn Figee (ORCID: https://orcid.org/0000-0003-3679-284X)
- Ignacio Sáez (ORCID: https://orcid.org/0000-0003-0651-2069)
- Matthew Heflin (ORCID: https://orcid.org/0000-0002-0379-3582)
- Thomas Twomey (ORCID: https://orcid.org/0009-0001-1779-7293)
- Kenneth T. Kishida (ORCID: https://orcid.org/0000-0002-7394-8922)
- Kaustubh Kulkarni (ORCID: https://orcid.org/0000-0001-6526-4873)
- Tanya Nauvel (ORCID: https://orcid.org/0009-0001-7185-2337)
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Terry Lohrenz (ORCID: https://orcid.org/0000-0002-1581-0765)
- Dan Bang (ORCID: https://orcid.org/0000-0001-7446-7090)
- Ha Neul Song (ORCID: https://orcid.org/0000-0001-7085-6988)
- Stephen Heisig (ORCID: https://orcid.org/0000-0001-8096-1730)
- Jason P. White (ORCID: https://orcid.org/0000-0003-1754-3768)
- Leonardo Barbosa Silva (ORCID: https://orcid.org/0000-0002-2464-8632)
- Ki Sueng Choi (ORCID: https://orcid.org/0000-0002-6446-0677)
- William M. Howe (ORCID: https://orcid.org/0000-0003-0433-6591)
- P. Read Montague (ORCID: https://orcid.org/0000-0002-8967-0339)
- Rosalyn Moran (ORCID: https://orcid.org/0000-0002-2736-2621)
- Anne S. Davis (ORCID: https://orcid.org/0000-0002-8200-8852)
- Blair Shevlin (ORCID: https://orcid.org/0000-0002-5420-0046)
- Alec Hartle (ORCID: https://orcid.org/0000-0002-4089-5473)
- Qi Xiu Fu (ORCID: https://orcid.org/0009-0001-2053-2659)
- Vincenzo G. Fiore (ORCID: https://orcid.org/0000-0002-4865-5482)
- Shannon O’Neill
- Isha Trivedi (ORCID: https://orcid.org/0009-0004-0654-9886)
Institutions
- Georgia Institute of Technology (US)
- King's College London (GB)
- Aarhus University (DK)
- Biomedical Research Institute (US)
- Wake Forest University (US)
- Virginia Tech (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-02
- DOI
- https://doi.org/10.64898/2025.11.28.691184
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00