Evaluating the effects of CD8/CD4 on T cell function in terms of TCR–pMHC–coreceptor catch and slip bonds
Our findings highlight the importance of force in antigen recognition by the TCR and reveal that parameters derived from the bond profile, especially in the presence of coreceptor, are more informative predictors of T cell activation compared to conventional affinity-based measurements. These results offer mechanistic insights into the roles of catch bonds and coreceptors in TCR antigen recognition.
Authors
- Peiwen Cong (ORCID: https://orcid.org/0000-0001-7753-8368)
- Larissa Doudy (ORCID: https://orcid.org/0009-0009-5761-8729)
- Hyun‐Kyu Choi (ORCID: https://orcid.org/0000-0003-4056-8736)
- Stefano Travaglino (ORCID: https://orcid.org/0000-0002-7362-2527)
- Cheng Zhu (ORCID: https://orcid.org/0000-0002-1718-565X)
- Menglan Li
- Amir Hossein Kazemipour Ashkezari (ORCID: https://orcid.org/0000-0002-7441-2927)
- Valencia Watson
Institutions
- Georgia Institute of Technology (US)
- Yonsei University (KR)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-03
- DOI
- https://doi.org/10.64898/2025.12.01.691627
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00