Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer’s disease
Our findings underscore the importance of LC in AD pathogenesis. Longitudinal measurement of LC degeneration may help distinguish trajectories of age-related cognitive decline and early AD.
Authors
- Jennifer Tremblay‐Mercier (ORCID: https://orcid.org/0000-0001-5824-3740)
- Colleen Hughes (ORCID: https://orcid.org/0000-0002-0632-4060)
- Judes Poirier
- Hayley R. C. Shanks (ORCID: https://orcid.org/0000-0003-4502-7170)
- Stéphane Lehéricy (ORCID: https://orcid.org/0000-0002-5802-3518)
- Rahul Gaurav (ORCID: https://orcid.org/0000-0001-9983-5873)
- Taylor W. Schmitz (ORCID: https://orcid.org/0000-0003-0585-7524)
- Sridar Narayanan (ORCID: https://orcid.org/0000-0002-6283-150X)
- John C.S. Breitner (ORCID: https://orcid.org/0000-0003-4229-4687)
- Kate M. Onuska (ORCID: https://orcid.org/0000-0001-6150-4403)
- Alfie Wearn (ORCID: https://orcid.org/0000-0001-7699-648X)
- R. Nathan Spreng (ORCID: https://orcid.org/0000-0003-1530-8916)
- Giulia Baracchini (ORCID: https://orcid.org/0000-0001-9198-2780)
- Gary R. Turner (ORCID: https://orcid.org/0000-0001-7232-8994)
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- York University (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- Sorbonne Université (FR)
- Indiana University Bloomington (US)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- McGill University (CA)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-05
- DOI
- https://doi.org/10.64898/2025.12.02.691923
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00