AKT signaling in hepatocytes rapidly increases glucose phosphorylation and contribution to glycogen without affecting metabolite pool sizes or glycogen breakdown
Together, these results demonstrate that AKT acutely regulates glucose contribution to glycogen and its upstream precursors, suggesting a transcription-independent, glucokinase-centered mechanism for glycogen synthesis through the direct pathway.
Authors
- Joseph A. Baur (ORCID: https://orcid.org/0000-0001-8262-6549)
- Paul M. Titchenell (ORCID: https://orcid.org/0000-0002-9941-5649)
- Joshua D. Rabinowitz (ORCID: https://orcid.org/0000-0002-1247-4727)
- Megan Stefkovich (ORCID: https://orcid.org/0000-0002-8983-5551)
- Won Dong Lee (ORCID: https://orcid.org/0000-0002-2344-171X)
- Talia Coopersmith
Institutions
- Yonsei University (KR)
- Ludwig Cancer Research (BE)
- Princeton University (US)
- University of the Arts (US)
- Penn Center for AIDS Research (US)
- Ludwig Cancer Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-03
- DOI
- https://doi.org/10.64898/2025.12.01.691331
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 0.00