Gingival Crevicular Fluid Proteomic Shift: From Gingivitis to Periodontitis
This proteomic profiling reveals complement-to-neutrophil transition from gingivitis to periodontitis, enabling stage-specific diagnosis since current clinical markers cannot distinguish inflammatory mechanisms. The identified protein markers are likely to provide objective molecular evidence for evaluating disease progression, potentially improving early intervention timing and treatment selection compared to traditional clinical measurements alone.
Authors
- Jeong-Hun Mok (ORCID: https://orcid.org/0000-0002-8832-6587)
- Minjoong Joo (ORCID: https://orcid.org/0000-0002-8286-187X)
- Ji‐Youn Hong (ORCID: https://orcid.org/0000-0003-1040-7077)
- Jeong‐Ho Yun (ORCID: https://orcid.org/0000-0003-3929-4467)
- Jong‐Moon Park (ORCID: https://orcid.org/0000-0002-4407-1383)
Institutions
- Gachon University (KR)
- Gachon University Gil Medical Center (KR)
- Jeonbuk National University Hospital (KR)
- Kyung Hee University Dental Hospital (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1016/j.identj.2025.109306
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00