Human Mediodorsal Thalamus in Seizure Propagation
The thalamic MD subregion was often involved after the other thalamic sites, but the MD sites, along with the massa intermedia connecting the two thalami, were significantly involved when seizures spread to contralateral hemisphere. Our findings suggest that a single thalamic lead capturing both MD subregions may yield important clinical information about laterality, origin, and generalization of seizures.
Authors
- Eric van Staalduinen
- Aida Risman
- Robert S. Fisher (ORCID: https://orcid.org/0000-0003-0287-613X)
- Josef Parvizi (ORCID: https://orcid.org/0000-0001-8520-7948)
- Vivek Buch (ORCID: https://orcid.org/0000-0003-1151-6128)
- Sofia Pantis (ORCID: https://orcid.org/0009-0004-7761-9095)
- Lu Yang (ORCID: https://orcid.org/0000-0001-7261-3007)
- Masaya Togo (ORCID: https://orcid.org/0000-0003-4780-0868)
- Olivia Marais
- Chipi Lozano
Institutions
- Stanford Medicine (US)
- Cognitive Neuroimaging Lab (FR)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-03
- DOI
- https://doi.org/10.64898/2025.12.01.691640
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00