Cosolvent Effects Question the Role of Water in Native Chemical Ligation
Guanidine hydrochloride and acetonitrile strongly inhibit native chemical ligation (NCL). These effects, considered alongside the impact of the cosolvents on the water structure, suggest that water actively participates in NCL.
Authors
- Vincent Diemer (ORCID: https://orcid.org/0000-0002-5735-4630)
- Vangelis Agouridas (ORCID: https://orcid.org/0000-0003-0911-1527)
- Oleg Melnyk (ORCID: https://orcid.org/0000-0002-3863-5613)
- Julie Di Adamo (ORCID: https://orcid.org/0009-0005-2433-5598)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Center for Infection and Immunity of Lille (FR)
- École Centrale de Lille (FR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04570
- Primary Topic
- Protein Structure and Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00