Transient Directing Group Enabled Nickel-Catalyzed Satoh–Miura Annulation of Free Benzylamines with Alkynes
We report a nickel-catalyzed Satoh-Miura annulation of free benzylamines with alkynes, enabled by a transient directing group (TDG) strategy. The integration of the TDG approach with earth-abundant nickel catalysis provides a straightforward and efficient route for the synthesis of substituted 1-naphthylmethylamines, which exhibits excellent functional group tolerance. Compared with conventional directing group (DG)-directed precious-metal-catalyzed systems for polycyclic aromatic hydrocarbon (PAH) synthesis, this protocol demonstrates advantages in atom- and step-economy, cost effectiveness, and sustainability.
Authors
- Chen Ma (ORCID: https://orcid.org/0009-0003-6111-9646)
- Weiwei Li (ORCID: https://orcid.org/0000-0003-4780-0278)
- Shiming Fan (ORCID: https://orcid.org/0000-0001-9728-6380)
- Zhi‐Gang She (ORCID: https://orcid.org/0000-0001-9402-4166)
- Jinlong Liu (ORCID: https://orcid.org/0000-0002-8251-9601)
- Yi Ren (ORCID: https://orcid.org/0000-0002-3665-700X)
- Ying Kang (ORCID: https://orcid.org/0000-0001-9963-4318)
- Xue Meng (ORCID: https://orcid.org/0009-0004-7405-9192)
- Xinghao Cai
- Shouxin Liu (ORCID: https://orcid.org/0000-0003-4104-2971)
Institutions
- Hebei University of Science and Technology (CN)
- Hebei Chemical and Pharmaceutical College (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c03914
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00