Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer’s disease
Cerebrovascular reactivity (CVR) impairment occurred in 5xFAD mice only when vascular smooth muscle cell (VSMC) loss was present5xFAD mice exhibited prominent parenchymal but minimal vascular amyloid-β depositionVSMC developmental deficiency resulted in CVR impairment in a small-vessel disease (SVD) modelNeuroinflammation primarily altered baseline cerebral blood flow (CBF) without affecting CVR.
Authors
- Minmin Yao
- Hanzhang Lu (ORCID: https://orcid.org/0000-0003-3871-1564)
- Wenzhen Duan (ORCID: https://orcid.org/0000-0001-5933-6308)
- Zhiliang Wei (ORCID: https://orcid.org/0000-0002-8477-2440)
- Xiuli Yang (ORCID: https://orcid.org/0000-0001-8277-4285)
- Adnan Bibic (ORCID: https://orcid.org/0000-0001-8044-2906)
- Yuguo Li (ORCID: https://orcid.org/0009-0000-9812-5458)
Institutions
- Kennedy Krieger Institute (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-03
- DOI
- https://doi.org/10.64898/2025.12.01.691642
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16