Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer
Therapeutic resistance remains a major challenge in pancreatic cancer. Our findings shed light on the changes in the complex tumor microenvironment in response to chemotherapy and identify fibroblasts high in axonal-guidance genes that may drive tumor progression and chemoresistance, thus uncovering a potential avenue for targeting pancreatic cancer.
Authors
- Richard S. Kwon (ORCID: https://orcid.org/0000-0002-4652-1106)
- Ahmed M. Elhossiny (ORCID: https://orcid.org/0000-0003-0884-8754)
- George Philips (ORCID: https://orcid.org/0009-0008-7304-721X)
- Eileen S. Carpenter (ORCID: https://orcid.org/0000-0001-6775-6943)
- Aylin Z. Henstridge (ORCID: https://orcid.org/0000-0003-1517-8306)
- Mark Joseph Truty (ORCID: https://orcid.org/0000-0003-3776-527X)
- Nicole Peterson (ORCID: https://orcid.org/0009-0000-6035-4124)
- Jonathan Y. Xia (ORCID: https://orcid.org/0000-0003-1225-2566)
- Filip Bednar (ORCID: https://orcid.org/0000-0001-5193-9817)
- Allison R. Schulman (ORCID: https://orcid.org/0000-0002-3913-8045)
- Padma Kadiyala (ORCID: https://orcid.org/0000-0002-3273-9905)
- Marina Pasca di Magliano (ORCID: https://orcid.org/0000-0001-9632-9035)
- Martín E. Fernández-Zapico (ORCID: https://orcid.org/0000-0002-8089-3907)
- Jorge D. Machicado (ORCID: https://orcid.org/0000-0002-2065-1367)
- Stacy B. Menees (ORCID: https://orcid.org/0000-0002-5891-4118)
- Vaibhav Sahai (ORCID: https://orcid.org/0000-0003-1892-1548)
- Costas Andreas Lyssiotis (ORCID: https://orcid.org/0000-0001-9309-6141)
- Jiaqi Shi (ORCID: https://orcid.org/0000-0002-8458-2364)
- Timothy L. Frankel (ORCID: https://orcid.org/0000-0001-5987-0404)
- Erik Wamsteker
- Nandini Arya (ORCID: https://orcid.org/0009-0002-2289-4423)
- Georgina Branch (ORCID: https://orcid.org/0009-0009-6270-3354)
Institutions
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Michigan Center for Translational Pathology (US)
- Michigan Cancer Research Consortium (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-05
- DOI
- https://doi.org/10.64898/2025.12.01.691614
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00