Beyond Cell Cycle Control: <i>CDKN2A</i> Loss Orchestrates NAD <sup>+</sup> Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma
While <i>CDKN2A</i> loss is classically associated with cell cycle deregulation through the p16-Cdk4-Rb axis, our findings suggest an additional layer of metabolic vulnerability arising from altered NAD homeostasis in <i>CDKN2A</i> -deleted glioblastoma, revealing a previously unrecognized metabolic-genetic interface for rationally revisiting NAD <sup>+</sup> targeting strategies, moving beyond the broad inhibition approaches.
Authors
- David A. Nathanson (ORCID: https://orcid.org/0000-0002-4919-9159)
- Swati Dubey (ORCID: https://orcid.org/0000-0003-1632-7940)
- Albert Lai (ORCID: https://orcid.org/0000-0002-7265-2986)
- Gang Yu (ORCID: https://orcid.org/0000-0002-3184-9045)
- Christopher Tse
- Fausto J. Rodríguez (ORCID: https://orcid.org/0000-0001-8662-1219)
- Ryana Aboul-Hosn
- Keith Vossel
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-04
- DOI
- https://doi.org/10.64898/2025.12.02.691903
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00